Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Ever Carradine Guest Star Amanda MacDonald Guest Star Kim Morgan Greene Guest Star Russell Hornsby Guest Star Sarah Utterback Guest Star Joseph Kell Guest Star Regan Forman Guest Star Bill Birch Guest Star Larry Cahn Guest Star Doug Sinclair Guest Star Steve Monroe Guest Star Shenita Moore Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Kip Koenig Writer Darnell Martin Director