Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Guest Star Lauren Bowles Guest Star Wayne Wilderson Guest Star Wendy Davis Guest Star Catherine Dao Guest Star Joyce Guy Guest Star Patty McCormack Guest Star Jack Merrill Guest Star Robin Pearson Rose Guest Star Jack Shearer Guest Star Sarah Utterback Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Harry Werksman Writer Gabrielle G. Stanton Writer Wendey Stanzler Director