Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Mimi Kennedy Guest Star Francois Chau Guest Star Brent Briscoe Guest Star Michelle Krusiec Guest Star Daniel Bess Guest Star Steven W. Bailey Guest Star Kate Burton Guest Star Sean Moran Guest Star Sally Ann Brooks Guest Star Bashir Salahuddin Guest Star Jeremy Rabb Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Mark Tinker Director