Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Joseph Sikora Guest Star Michelle Ongkingco Guest Star Patti Yasutake Guest Star Francis Guinan Guest Star Tyrees Allen Guest Star Elaine Kagan Guest Star Reni Santoni Guest Star Steven W. Bailey Guest Star Moe Irvin Guest Star Alison Ward Guest Star Cathy Lind Hayes Guest Star Kerry Carney Guest Star Maile Flanagan Guest Star Peyton Hinson Guest Star Keeshan Giles Guest Star Larry Weissman Guest Star Gianin Loffler Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Stacy McKee Writer Adam Davidson Director