Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Shelley Berman Guest Star Joseph Lyle Taylor Guest Star Arija Bareikis Guest Star Geoffrey Rivas Guest Star Janet Rotblatt Guest Star Brittany Ishibashi Guest Star Kate Blumberg Guest Star Kai Lennox Guest Star Kathleen M. Darcy Guest Star Ray Ford Guest Star Linda Klein Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Mimi Schmir Writer Lesli Linka Glatter Director