Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Brian Kerwin Guest Star Greg Pitts Guest Star Tim Griffin Guest Star Sarah Utterback Guest Star Steven W. Bailey Guest Star Andrew James Allen Guest Star Michael Matthys Guest Star Dee Nelson Guest Star Mike Faiola Guest Star Peter Howard Guest Star Jack Yang Guest Star Gregor Manns Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Michael Dinner Director