Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor James Pickens Jr. Dr. Richard Webber Actor T.R. Knight Dr. George O'Malley Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Chandra Wilson Dr. Miranda Bailey Actor Isaiah Washington Dr. Preston Burke Actor Justin Chambers Dr. Alex Karev Actor Kate Walsh Dr. Addison Montgomery Actor Natalie Cole Guest Star Jeffrey Dean Morgan Guest Star Sara Ramirez Guest Star Anne Moore Guest Star Teddy Dunn Guest Star Stephen Lee Guest Star Tim Rhoze Guest Star Kelley Hazen Guest Star Ray Ford Guest Star Helene McCardle Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Gabrielle G. Stanton Writer Harry Werksman Writer Julie Anne Robinson Director