Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Elizabeth Reaser Guest Star Kali Rocha Guest Star Dean Norris Guest Star Kelly Wolf Guest Star Paul Perri Guest Star Jeffrey Dean Morgan Guest Star Kyle Chandler Guest Star Jeffrey Markle Guest Star Billy Mayo Guest Star Brian Chenoweth Guest Star Danielle Kennedy Guest Star Paul Norwood Guest Star Madison Leisle Guest Star Moe Irvin Guest Star Kate Anthony Guest Star Shenita Moore Guest Star Yvans Jourdain Guest Star Jonah Bay Guest Star Liza De Weerd Guest Star Mac Brandt Guest Star Tim Chiou Guest Star John Koyama Guest Star Marlon John Guest Star Akeem Smith Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Rob Corn Director