Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Jeffrey Dean Morgan Guest Star Kyle Chandler Guest Star Elizabeth Reaser Guest Star Anna Maria Horsford Guest Star Monica Keena Guest Star Kali Rocha Guest Star Steven W. Bailey Guest Star Sarah Utterback Guest Star Kate Burton Guest Star Moe Irvin Guest Star David Downs Guest Star Yvette Cruise Guest Star Billy Wood Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Marti Noxon Writer Adam Arkin Director