Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Isaiah Washington Dr. Preston Burke Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Kate Walsh Dr. Addison Montgomery Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Paul Adelstein Guest Star Amy Brenneman Guest Star Tim Daly Guest Star Taye Diggs Guest Star Merrin Dungey Guest Star Christopher Lowell Guest Star Diahann Carroll Guest Star Elizabeth Reaser Guest Star Jeff Perry Guest Star D.W. Moffett Guest Star Bellamy Young Guest Star Raphael Sbarge Guest Star Stephanie Niznik Guest Star Tsai Chin Guest Star David Anders Guest Star Becky Wahlstrom Guest Star Cameron Watson Guest Star Gary Hershberger Guest Star Parisa Fitz-Henley Guest Star Shavon Kirksey Guest Star Mare Winningham Guest Star Mary Joy Guest Star Garon Grigsby Guest Star Jane Clark Guest Star William B. Jackson Guest Star Robin Hines Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Michael Grossman Director