Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Brooke Smith Dr. Erica Hahn Actor Amy Madigan Guest Star Elizabeth Reaser Guest Star Lauren Stamile Guest Star Molly Kidder Guest Star Ray Ford Guest Star Joy Osmanski Guest Star Mark Saul Guest Star Joseph Williamson Guest Star Shonda Rhimes Executive Producer, Writer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Krista Vernoff Writer Tony Phelan Writer Stacy McKee Writer Mark Wilding Writer Debora Cahn Writer Allan Heinberg Writer Zoanne Clack Writer Rob Corn Director James Frawley Director Joan Rater Writer Daniel Minahan Director Randy Zisk Director Tom Verica Director Mark Tinker Director Julie Anne Robinson Director