Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Edward Herrmann Guest Star Michael McGrady Guest Star Matt Lanter Guest Star Maggie Siff Guest Star Miriam Flynn Guest Star Camille Winbush Guest Star Ron Melendez Guest Star Loretta Devine Guest Star Shelley Robertson Guest Star Jeremy Rabb Guest Star Maile Flanagan Guest Star Tymberlee Hill Guest Star Gloria Garayua Guest Star Richard Keith Guest Star Molly Kidder Guest Star Joy Osmanski Guest Star Mark Saul Guest Star Winston Story Guest Star Cassandra Braden Guest Star Nicole Rubio Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Allan Heinberg Writer Randy Zisk Director