Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Brooke Smith Dr. Erica Hahn Actor Kevin McKidd Owen Hunt Guest Star Jeffrey Dean Morgan Guest Star Tom Verica Guest Star Bonnie Bartlett Guest Star George Coe Guest Star Brandon Scott Guest Star Avery Clyde Guest Star Gloria Garayua Guest Star Mark Saul Guest Star Fidel Gomez Guest Star Shi Ne Nielson Guest Star Gordon James Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer William Harper Writer Joanna Kerns Director