Ellen Pompeo Dr. Meredith Grey Actor Patrick Dempsey Dr. Derek Shepherd Actor Sandra Oh Dr. Cristina Yang Actor Katherine Heigl Dr. Izzie Stevens Actor Justin Chambers Dr. Alex Karev Actor T.R. Knight Dr. George O'Malley Actor Chandra Wilson Dr. Miranda Bailey Actor James Pickens Jr. Dr. Richard Webber Actor Sara Ramirez Dr. Callie Torres Actor Eric Dane Dr. Mark Sloan Actor Chyler Leigh Dr. Lexie Grey Actor Kevin McKidd Owen Hunt Actor Kimberly Elise Guest Star Jessica Capshaw Guest Star Obba Babatundé Guest Star José Zúñiga Guest Star Elden Henson Guest Star Héctor Elizondo Guest Star Amy Madigan Guest Star Carlease Burke Guest Star Mary-Charles Jones Guest Star Regi Davis Guest Star Moe Irvin Guest Star Nicole Rubio Guest Star Mac Brandt Guest Star Shonda Rhimes Executive Producer Mark Gordon Executive Producer Betsy Beers Executive Producer James D. Parriott Executive Producer Sonay Washington Writer Tony Phelan Director