James Arness Marshal Matt Dillion Actor Milburn Stone Dr. Galen "Doc" Adams Actor Amanda Blake Kitty Russell Actor Ken Curtis Festus Guest Star Roger Ewing Thad Guest Star Glenn Strange Sam Noonan Guest Star Ted Jordan Nathan Burke Guest Star Claude Akins Worth Sweeney Guest Star Josephine Hutchinson Sister Ellen Guest Star Aneta Corsaut Sister Ruth Guest Star Kelly Jean Peters Sister John Guest Star Venita Wolf Sister Margaret Guest Star Lois Roberts Sister Louise Guest Star Henry Darrow Ross Segurra Guest Star Vic Tayback Ike Gaines Guest Star Ralph Roberts Williams Guest Star John Carter Doyle Guest Star Lew Brown Gaines' Brother Guest Star John Mantley Producer Norman MacDonnell Producer