Rachel Bilson Dr. Zoe Hart Actor Jaime King Lemon Breeland Actor Wilson Bethel Wade Kinsella Actor Cress Williams Lavon Hayes Actor Scott Porter George Tucker Actor Nicholas Pryor Dr. Harley Wilkes Guest Star Tim Matheson Dr. Brick Breeland Guest Star JoBeth Williams Candice Hart Guest Star Ann Mahoney Mabel Guest Star Bruce Altman Surgical Chief Guest Star Nancy Travis Emmeline Hattenbarger Guest Star Robin Mullins Colleen Guest Star Moses Gibson Old Man Jackson Guest Star Leila Gerstein Executive Producer, Writer Josh Schwartz Executive Producer Stephanie Savage Executive Producer Len Goldstein Executive Producer Jason Ensler Executive Producer, Director