Hugh Laurie Dr. Gregory House Actor Lisa Edelstein Dr. Lisa Cuddy Actor Robert Sean Leonard Dr. James Wilson Actor Jennifer Morrison Dr. Allison Cameron Actor Omar Epps Dr. Eric Foreman Actor Jesse Spencer Dr. Robert Chase Actor Sasha Pieterse Andie Guest Star Jewel Christian Pam Guest Star Stephanie Venditto Nurse Brenda Previn Guest Star Randall Park Brad Guest Star William Jones Dr. Murphy Guest Star Eamon Hunt Neurosurgeon 1 Guest Star Gwen Holloway Neurosurgeon 2 Guest Star Hira Ambrosino Dr. Chen, Anesthesiologist Guest Star Jonathan Fraser Motorbike Salesman Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer Deran Sarafian Director Lawrence Kaplow Writer