Hugh Laurie Dr. Gregory House Actor Lisa Edelstein Dr. Lisa Cuddy Actor Omar Epps Dr. Eric Foreman Actor Robert Sean Leonard Dr. James Wilson Actor Jennifer Morrison Dr. Allison Cameron Actor Jesse Spencer Dr. Robert Chase Actor Braeden Lemasters Adam Guest Star Geoffrey Blake Dominic Guest Star Heather Kafka Sarah Kelvey Guest Star Leighton Meester Ali Guest Star Stephanie Venditto Nurse Brenda Previn Guest Star Kat Sawyer Laura Smith Guest Star Johnny Crear Thomas Williams Guest Star Ron Perkins Dr. Ron Simpson Guest Star Bobbin Bergstrom Nurse Guest Star Shawn McDonald EMT Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer Newton Thomas Sigel Director David Hoselton Writer