Hugh Laurie Dr. Gregory House Actor Lisa Edelstein Dr. Lisa Cuddy Actor Omar Epps Dr. Eric Foreman Actor Robert Sean Leonard Dr. James Wilson Actor Jennifer Morrison Dr. Allison Cameron Actor Jesse Spencer Dr. Robert Chase Actor Mira Sorvino Dr. Cate Milton Guest Star Peter Jacobson Dr. Chris Taub Guest Star Kal Penn Dr. Lawrence Kutner Guest Star Olivia Wilde Thirteen, Dr. Remy Hadley Guest Star Jeff Hephner Seth Guest Star Anne Dudek Dr. Amber Volakis Guest Star Bobbin Bergstrom Nurse Guest Star Paul Attanasio Executive Producer Katie Jacobs Executive Producer David Shore Executive Producer Bryan Singer Executive Producer David Straiton Director Liz Friedman Writer