Damon Wayans Roger Murtaugh Actor Seann William Scott Wesley Cole Actor Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Maggie Lawson Natalie Flynn Guest Star Shay Rudolph Maya Guest Star Nick Searcy Ray Guest Star Russell Wong Stan Guest Star Burton Perez Luca Chavez Guest Star Christian Ochoa Lavernia Darwin Perez Guest Star Jonathan Sadowski Andrew Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer