Damon Wayans Roger Murtaugh Actor Seann William Scott Wesley Cole Actor Kevin Rahm Captain Brooks Avery Actor Jordana Brewster Dr. Maureen "Mo" Cahill Actor Keesha Sharp Trish Murtaugh Actor Johnathan Fernandez Scorsese Actor Michelle Mitchenor Detective Bailey Actor Dante Brown Roger Murtaugh Jr. Actor Chandler Kinney Riana Murtaugh Actor Nishi Munshi Erica Guest Star Sean Blakemore Barrett Guest Star Anna Khaja Senator Malick Guest Star Cliff Chamberlain Stuart Stevenson Guest Star Matt Miller Executive Producer McG Executive Producer Dan Lin Executive Producer Jennifer Gwartz Executive Producer