Michael Sheen William Masters Actor, Producer Lizzy Caplan Virginia Johnson Actor Caitlin FitzGerald Libby Masters Actor Teddy Sears Dr. Austin Langham Actor Annaleigh Ashford Betty DiMello Actor Ann Dowd Guest Star Betsy Brandt Guest Star Kevin Christy Guest Star Jocko Sims Guest Star Marin Ireland Guest Star John Billingsley Guest Star Sterling K. Brown Guest Star Erin Cummings Guest Star Larry Joshua Guest Star Christian Borle Guest Star Michelle Ashford Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Judith Verno Executive Producer Amy Lippman Executive Producer, Writer Jeremy Webb Director