Dylan Walsh Dr. Sean McNamara Actor Julian McMahon Dr. Christian Troy Actor John Hensley Matt McNamara Actor Joely Richardson Julia McNamara Actor Valerie Cruz Grace Santiago Actor Sophia Bush Ridley Lange Guest Star Jessalyn Gilsig Gina Russo Guest Star Leslie Grossman Bliss Berger Guest Star Kate Mara Vanessa Bartholomew Guest Star Julie Warner Megan O'Hara Guest Star David Barrera Policeman Guest Star Kelly Carlson Kimber Henry Guest Star Rick Kelly Jim O'Hara Guest Star Luis Antonio Ramos Nico Scamarel Guest Star Harry Karp Isaac Guest Star Linda Klein Nurse Linda Guest Star