Dylan Walsh Dr. Sean McNamara Actor Julian McMahon Dr. Christian Troy Actor John Hensley Matt McNamara Actor Joely Richardson Julia McNamara Actor Roma Maffia Dr. Liz Cruz Actor Kelly Carlson Kimber Henry Actor Oliver Platt Freddy Prune Guest Star Portia de Rossi Olivia Lord Guest Star Rosie O'Donnell Dawn Budge Guest Star Paula Marshall Kate Tinsley Guest Star AnnaLynne McCord Eden Lord Guest Star Claudia Christian Gwen Guest Star Tamara Marie Watson Nun Guest Star Kelsey Batelaan Annie McNamara Guest Star Jack Plotnick Dr. George Guest Star Michael Monks Mr. Blunt Guest Star Dot Marie Jones Tess Guest Star Linda Klein Nurse Linda Guest Star Eli Jane Model Guest Star