With luggage still in tow, the designers are greeted at the TWA Hotel at John F. Kennedy International Airport ready to take flight with their first challenge to create an innovative look inspired by humanity's continued push into space exploration.

Designers must create a fresh take on a timeless classic: animal prints; taking inspiration from the 2019 movie, "Cats," the designers must tame their prints to create stylish looks that can compete on the runway and in the Flash Sale challenge.

The designers are awakened by a surprise visitor; the designers are challenged to show their holiday spirit in the perfect party dress; channeling their own holiday memories, the designers must transform a winter wonderland into a wearable wonder.

Guest mentor Karla Welch tasks the designers with dressing her client, Karlie Kloss; the designers must recycle donated clothing from a Goodwill store to create their looks, and they must be both resourceful and fast for this one-day challenge.

Singer Cyndi Lauper inspires and guest judges a team challenge; the designers must create cohesive mini-collections paying homage to Lauper's 1980s fashion style with a modern take; Christian throws out a mid-challenge twist that changes everything.

The designers are challenged to think about their family histories and channel those stories into a look of their choosing; the stakes are high in this one-day challenge, as the designers must face and embrace who they are in order to succeed.

Collaborations between fashion designers and artists are all the rage; the designers get a chance to enter into one with painter Ashley Longshore whose outrageous pop art gives the runway some of the boldest looks of the season.

The designers face a one-day challenge using sexy, sheer fabrics; staying in the game becomes more and more difficult for several designers who are reaching their personal limits and question their ability to make it to the end.

The challenge is all about turning the tuxedo on its head; inspired by Christian Siriano's Oscar look for actor Billy Porter, the designers must find a way to take the tuxedo into the future with a mix of male, female and non-binary models.

Tie dye is back in a big way, and the designers will need to create their own textiles to elevate the trend from casual to couture; in a twist that may feel more like a trick to the designers, it's an overnight challenge.