Emma Roberts Chanel Oberlin Actor Jamie Lee Curtis Dean Cathy Munsch Actor, Director Lea Michele Hester Actor Abigail Breslin Chanel No. 5 Actor Billie Lourd Chanel No. 3 Actor Keke Palmer Zayday Williams Actor John Stamos Dr. Brock Holt Actor Taylor Lautner Dr. Cassidy Cascade Actor Kirstie Alley Nurse Hoffel Actor James Earl Chamberlain Jackson Actor Trilby Glover Guest Star Andy Erikson Guest Star Riley McKenna Weinstein Guest Star Bill Oberst Jr. Guest Star Ryan Murphy Executive Producer Brad Falchuk Executive Producer Ian Brennan Executive Producer Alexis Martin Woodall Executive Producer