Melissa Benoist Kara Danvers, Supergirl Actor Chyler Leigh Alex Danvers Actor Mehcad Brooks James Olsen Actor David Harewood Hank Henshaw Actor Jeremy Jordan Winslow "Winn" Schott Actor Chris Wood Mon-El Actor Katie McGrath Lena Luthor Actor Odette Annable Samantha Arias, Reign Actor Amy Jackson Imra Ardeen, Saturn Girl Guest Star Krys Marshall Julia Freeman, Purity Guest Star Angela Zhou Dr. Grace Parker, Pestilence Guest Star Anjali Jay Selena Guest Star Greg Berlanti Executive Producer Allison Adler Executive Producer Andrew Kreisberg Executive Producer Sarah Schechter Executive Producer Caitlin Parrish Director, Writer Erica Weiss Director Jessica Queller Writer Derek Simon Writer