Rob Lowe Sam Seaborn Actor Martin Sheen President Josiah "Jed" Bartlet Actor Bradley Whitford Dep. Chief of Staff Josh Lyman Actor John Spencer Chief of Staff Leo McGarry Actor Richard Schiff Communications Dir. Toby Ziegler Actor Allison Janney Press Secretary Claudia Jean "C.J." Cregg Actor Dulé Hill Charlie Young Actor Janel Moloney Donna Moss Actor Stockard Channing Abigail "Abbey" Bartlet Actor Marlee Matlin Joey Lucas Guest Star Mary-Louise Parker Amy Gardner Guest Star Traylor Howard Lisa Shureborn Guest Star Bill O'Brien Kenny Thurman Guest Star Nancy Linehan Charles Oncologist 1 Guest Star Howard S. Miller Dr. Ken Walker Guest Star Nicholas Hormann Oncologist Bobby Guest Star Brian Baker John Tandy Guest Star Charles Walker Oncologist 3 Guest Star Kim Webster Ginger Guest Star Peter James Smith Ed Guest Star Aaron Sorkin Executive Producer Thomas Schlamme Executive Producer John Wells Executive Producer Michael Hissrich Producer Alex Graves Producer Kristin Harms Producer Llewellyn Wells Producer David Nutter Director