Chuck Lorre Creator Michael Douglas Sandy Kominsky Actor, Executive Producer Alan Arkin Norman Newlander Actor Sarah Baker Mindy Kominsky Actor Nancy Travis Lisa Actor Lisa Edelstein Actor Susan Sullivan Actor Paul Reiser Actor Jane Seymour Actor Kathleen Turner Actor Haley Joel Osment Actor Danny DeVito Actor Melissa Tang Actor Casey Thomas Brown Actor Jenna Lyng Adams Actor Ashleigh LaThrop Actor Emily Osment Actor Ann-Margret Actor Graham Rogers Actor Alan J. Higgins Executive Producer