Justin Haythe Creator Samantha Morton Catherine de Medici Actor Amrita Acharia Aabis Actor Barry Atsma Montmorency Actor Enzo Cilenti Ruggieri Actor Sennia Nanua Rahima Actor Liv Hill Young Catherine Actor Charles Dance Pope Clement Actor Colm Meaney King Francis Actor Raza Jaffrey Francois Guise Actor Ray Panthaki Charles Guise Actor Nicholas Burns Antoine de Bourbon Actor Danny Kirrane Louis de Bourbon Actor Kiruna Stamell Mathilde Actor Antonia Clarke Mary Queen of Scots Actor Adam Garcia Actor Naomi Battrick Anna D'Etampes Actor Rebecca Gethings Queen Eleanor Actor George Jaques Francis II Actor Jade Croot Edith Actor