Justin Haythe Creator, Executive Producer, Writer Samantha Morton Catherine De Medici Actor Charles Dance Pope Clement Actor Amrita Acharia Aabis Actor Colm Meaney King Francis Actor Barry Atsma Montmorency Actor Adam Garcia Actor Raza Jaffrey Francois Guise Actor Naomi Battrick Anna D'Etampes Actor Ray Panthaki Charles Guise Actor Enzo Cilenti Ruggieri Actor Nicholas Burns Antoine de Bourbon Actor Sennia Nanua Rahima Actor Danny Kirrane Louis de Bourbon Actor Rebecca Gethings Queen Eleanor Actor Liv Hill Young Catherine Actor Kiruna Stamell Mathilde Actor Antonia Clarke Mary Queen of Scots Actor George Jaques Francis II Actor Jade Croot Edith Actor Francis Lawrence Executive Producer Erwin Stoff Executive Producer Elizabeth Chakkappan Writer Kate Dennis Director