Dan Castellaneta Homer Jay Simpson, Barney Gumble, Grampa Simpson, Mayor Joe Quimby, Krusty the Klown, Groundskeeper Willie Voice Julie Kavner Marjorie Bouvier Simpson, Patty Bouvier, Selma Bouvier, Grandma Jackie Bouvier Voice Nancy Cartwright Bartholomew Jo-Jo "Bart" Simpson, Nelson Muntz Voice Yeardley Smith Lisa Marie Simpson Voice Hank Azaria Moe Szyslak, Apu Nahasapeemapetilon, Chief Clancy Wiggum, Dr. Nick Riviera Voice Harry Shearer Charles Montgomery Burns, Waylon Smithers, Principal Seymour Skinner, Ned Flanders, Otto Mann, Scratchy, Kent Brockman, Dr. Julius Hibbert, Reverend Timothy Lovejoy Voice Stephen Colbert Colby Krause Guest Voice Lionel Richie Himself Guest Voice Pamela Hayden Milhouse Van Houten Guest Voice Tress MacNeille Dolph Guest Voice Karl Wiedergott Pilot 1 , Man in Audience , Guy at the Airport , Pilot 2 Guest Voice James L. Brooks Executive Producer Matt Groening Executive Producer Al Jean Executive Producer Mark Kirkland Director