David Kohan Creator, Executive Producer Max Mutchnick Creator, Executive Producer Eric McCormack Will Truman Actor Debra Messing Grace Adler Actor Sean Hayes Jack McFarland Actor Megan Mullally Karen Walker Actor Shelley Morrison Rosario Salazar Actor Gene Wilder Mr. Stein Guest Star Tim Bagley Larry Guest Star Harry Connick Jr. Leo Markus Guest Star Minnie Driver Lorraine Finster Guest Star Debbie Reynolds Bobbi Adler Guest Star Rosanna Arquette Julie Guest Star Eileen Brennan Zandra Guest Star Mary Beth McDonough Mom Guest Star Elton John Elton John Guest Star Kevin Bacon Kevin Bacon Guest Star Madonna Liz Guest Star Dan Futterman Barry Guest Star Rip Torn Lionel Banks Guest Star Katie Couric Herself Guest Star Nicollette Sheridan Dr. Danielle Morty Guest Star James Burrows Executive Producer, Director Jeff Greenstein Executive Producer, Writer Bill Wrubel Writer Sally Bradford Writer Adam Barr Writer Gary Janetti Writer Tracy Poust Writer Laura Kightlinger Writer Steve Gabriel Writer Kari Lizer Writer Jon Kinnally Writer Alex Herschlag Executive Producer, Writer Jhoni Marchinko Executive Producer