Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Ryan Phuong Tam Guest Star Valerie Mahaffey Ms. Macelroy Guest Star Wyatt McClure Billy Sparks Guest Star Brian Stepanek Mr. Givens Guest Star Danielle Pinnock Ms. Ingram Guest Star Julie Hagerty Ms. Hutchins Guest Star Cait Pool Lisa May Guest Star Murray Wyatt Rundus Clint Guest Star Tate Berney Dexter Guest Star Wiley Pickett FBI Agent 1 Guest Star Leonard Armond Robinson FBI Agent 2 Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Michael Zinberg Director