Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Rex Linn Principal Petersen Guest Star Brian Stepanek Mr. Givens Guest Star Jason Alexander Mr. Lundy Guest Star John Hartman Dr. Goetsch Guest Star Pam Cook Diane Guest Star Ava Cantrell Molly Guest Star Aliyah Moulden Pepper Guest Star Lily Keene Sueann Ludlow Guest Star Catherine H. Fisher July Guest Star Gabriella Martinez Kate Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Howard Deutch Director