Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Wallace Shawn Dr. John Sturgis Guest Star Rex Linn Principal Petersen Guest Star Ryan Phuong Tam Guest Star Matt Hobby Pastor Jeff Guest Star Brian Stepanek Mr. Givens Guest Star Valerie Mahaffey Ms. Macelroy Guest Star Nancy Linehan Charles Peg Guest Star Isabella Coben Nell Cavanaugh Guest Star Robert Clotworthy Mayor Harrison Guest Star Daniele Lawson Shelby Guest Star Annelise Grace Abby Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Damir Konjicija Writer Dario Konjicija Writer David Bickel Writer Steve Holland Writer Jude Weng Director