Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Wallace Shawn Dr. Sturgis Guest Star Craig T. Nelson Dale Guest Star Melissa Peterman Brenda Sparks Guest Star Ryan Phuong Tam Guest Star Wyatt McClure Billy Sparks Guest Star Isabel May Veronica Guest Star Kerri Medders Lisa Guest Star Miller Tai Clark Guest Star Corwin Allard Luke Guest Star Mac Jarman Rick Guest Star Chuck Lorre Executive Producer, Writer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Maria Ferrari Writer Tara Hernandez Writer Jeremy Howe Writer Jaffar Mahmood Director