Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Wallace Shawn Dr. Sturgis Guest Star Ava Allan Jana Guest Star Kerry O'Malley Fran Guest Star Amanda Payton Meredith Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Eric Kaplan Writer Maria Ferrari Writer Jeremy Howe Writer Steve Holland Writer Tara Hernandez Writer Jaffar Mahmood Director