Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Melissa Peterman Brenda Sparks Guest Star Wyatt McClure Billy Sparks Guest Star Ramiz Monsef Dr. Patel Guest Star Jill Johnson Gretchen Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Maria Ferrari Writer Tara Hernandez Writer Connor Kilpatrick Writer Steve Holland Writer Eric Kaplan Writer Jeremy Howe Director