Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Ed Begley Jr. Professor Linkletter Guest Star Melissa Peterman Brenda Sparks Guest Star Wyatt McClure Billy Sparks Guest Star Melanie Lynskey Professor Ericson Guest Star P.J. Ochlan Rene Descartes Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Tara Hernandez Writer Jeremy Howe Writer Connor Kilpatrick Writer Steve Holland Writer Eric Kaplan Writer Alex Reid Director