Iain Armitage Sheldon Actor Zoe Perry Mary Actor Lance Barber George Sr. Actor Annie Potts Meemaw Actor Montana Jordan Georgie Actor Raegan Revord Missy Actor Jim Parsons Adult Sheldon Narrator, Executive Producer Matt Hobby Pastor Jeff Actor Wallace Shawn Dr. Sturgis Guest Star Ed Begley Jr. Dr. Linkletter Guest Star Melissa Peterman Brenda Sparks Guest Star Brian Stepanek Mr. Givens Guest Star Sarah Baker Ms. Hutchins Guest Star Ryan Phuong Tam Guest Star Adrian Moreira-Behrens Donald Guest Star Chuck Lorre Executive Producer Steven Molaro Executive Producer, Writer Todd Spiewak Executive Producer Steve Holland Writer Tara Hernandez Writer Marie Cheng Writer Jeremy Howe Writer Connor Kilpatrick Writer Alex Reid Director