Patrick Wilson Dr. Michael Holt Actor Jennifer Ehle Anna Paul Actor Margo Martindale Rita Perkins-Hall Actor Pablo Schreiber Anton Little Creek Actor Rachelle Lefevre Dr. Kate Sykora Actor Rhys Coiro Dr. Zeke Barnes Guest Star Julie Benz Christina Holt Guest Star Afton Williamson Autumn Guest Star Adrian Martinez Hector Guest Star Sue Jean Kim Nurse Collette Guest Star Peter Hermann Harrison Curtis Guest Star Christina Milian Shawnee Baker Guest Star Ursula Parker Simona Albescu Guest Star Ylfa Edelstein Ileana Albescu Guest Star Michael Beach Nicky Davis Guest Star Peter Maloney Mr. Janowitz Guest Star Katie Ross Nurse Maria Guest Star Paul Sanderson Complaining Man Guest Star Paloma Guzman Kylie Trevane Guest Star Deborah Baum Bartender Guest Star Ben Nordstrom Businessman Guest Star Cameron Ocasio Boy with Ball Guest Star Susannah Grant Executive Producer Jonathan Demme Executive Producer Sarah Timberman Executive Producer Carl Beverly Executive Producer Neal Baer Executive Producer Dawn DeNoon Writer Eriq La Salle Director