Kathy Bates Iris Actor Sarah Paulson Hypodermic Sally Actor Evan Peters James March Actor Wes Bentley Detective John Lowe Actor Matt Bomer Donovan Actor Chloë Sevigny Dr. Alex Lowe Actor Denis O'Hare Liz Taylor Actor Cheyenne Jackson Will Drake Actor Angela Bassett Ramona Royale Actor Lady Gaga The Countess Actor Finn Wittrock Tristan Duffy Guest Star Mare Winningham Hazel Evers Guest Star Alexandra Daddario Natacha Rambova Guest Star Josh Braaten Douglas Pryor Guest Star Lennon Henry Holden Lowe Guest Star Ryan Murphy Executive Producer Brad Falchuk Executive Producer Tim Minear Executive Producer Bradley Buecker Executive Producer Jennifer Salt Executive Producer James Wong Executive Producer Alexis Martin Woodall Executive Producer