Tom Kapinos Creator, Executive Producer David Duchovny Hank Moody Actor, Executive Producer Natascha McElhone Karen Actor Madeleine Martin Becca Moody Actor Madeline Zima Mia Lewis Actor Evan Handler Charlie Runkle Actor Pamela Adlon Marcy Runkle Actor Rob Lowe Guest Star Stephen Tobolowsky Guest Star Michael Ealy Guest Star Addison Timlin Guest Star Melissa Stephens Guest Star Larry Poindexter Guest Star Jonathan Kasdan Guest Star Dawn Olivieri Guest Star Carla Gugino Guest Star Ana Rey Guest Star Angela Bullock Guest Star Danielle Soibelman Guest Star Shane Schoeppner Guest Star Lindsay Stuart Guest Star