Marcia Gay Harden Dr. Leanne Rorish Actor Boris Kodjoe Dr. Will Campbell Actor Melanie Chandra Dr. Malaya Pineda Actor Harry Ford Dr. Angus Leighton Actor Benjamin Hollingsworth Dr. Mario Savetti Actor Jillian Murray Dr. Heather Pinkney Actor William Allen Young Dr. Rollie Guthrie Actor Luis Guzmán Jesse Sallander Actor Rob Lowe Col. Ethan Willis Actor Noah Gray-Cabey Dr. Elliot Dixon Guest Star Emily Tyra Dr. Noa Kean Guest Star Nafessa Williams Dr. Charlotte Piel Guest Star Steven Culp Desmond Leighton Guest Star Kathleen Rose Perkins Amanda Nolan Guest Star Abigail Klein Eloise Guest Star Joshua Keller Katz Paramedic 1 Guest Star Brooklyn Silzer Erica Flynn Guest Star Duncan Joiner Ian Renwick Guest Star Joey Honsa Cheryl Guest Star Joshua Hoffman Tyler Guest Star Mary Kate Wiles Betsy Guest Star Ava Davila Mini-Jessamine Guest Star Terrence Edwards Paramedic 2 Guest Star Matthew Staley Logan Green Guest Star Jeffrey Damnit Skull Face Guest Star Brenda Arteaga-Walsh Mom Guest Star Bradley Snedeker John renwick Guest Star Omid Zader Sheriff Guest Star Michael Seitzman Executive Producer David Semel Executive Producer Ryan McGarry Executive Producer Marti Noxon Executive Producer Linda Goldstein Knowlton Executive Producer Michael Brandon Guercio Writer Luis Prieto Director