Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor Jeananne Goossen Officer Lauren Cooper Guest Star Tim Guinee Nathan Purdue Guest Star Elizabeth Braun Michelle Moore Guest Star Courtney Ford Nicole Moore Guest Star Michelle Page Audrey Noonan Guest Star Jonathan Schmock Guest Star Michael Cotter Harry Rose Guest Star Laura Ornelas Jamie Fisher Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer Adam Targum Writer Nathan Hope Director