Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor Megan Dodds Christine Whitney Guest Star James Shanklin Michael Byrne Guest Star Molly Burnett Molly Byrne Guest Star Billy Lush Kieran Reilly Guest Star Mickey Cassidy Guest Star Chris Gartin Dan Coleman Guest Star Ryan Happy Guest Star Jayk Gallagher Guest Star Ariel Teal Toombs Guest Star Kevin Vyce Guest Star Marc Worden Declan Callahan Guest Star Julie Arebalo E.R. Doctor 1 Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer Sarah Byrd Writer Christine Moore Director