Gary Sinise Det. Mack "Mac" Taylor Actor Sela Ward Jo Danville Actor Carmine Giovinazzo Det. Danny Messer Actor Hill Harper Dr. Sheldon Hawkes Actor Eddie Cahill Det. Donald Flack, Jr. Actor Anna Belknap Det. Lindsay Monroe Messer Actor A.J. Buckley Adam Ross Actor Robert Joy Dr. Sid Hammerback Actor Natalie Martinez Guest Star Kathleen Munroe Samantha Flack Guest Star Austin Kane Guest Star Meredith Monroe Mrs. Lewis Guest Star Alex Carter Nathan Lewis Guest Star Jamie McShane Mitch Ventri Guest Star Zack Ward Keith Milner Guest Star Brooklyn McLinn Tony Davis Guest Star Elaine Kagan Guest Star Len Cordova Guest Star Luc Austin Guest Star Brooke Robinson Guest Star Megan Dodds Christine Whitney Guest Star Karina Logue Guest Star Michael Antonacci Guest Star Jerry Bruckheimer Executive Producer Carol Mendelsohn Executive Producer Ann Donahue Executive Producer Anthony Zuiker Executive Producer Danny Cannon Executive Producer Andrew Lipsitz Executive Producer John Dove Writer Nathan Hope Director