Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Dr. Joan Watson Actor Aidan Quinn Capt. Tobias "Toby" Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Vinnie Jones Sebastian Moran Guest Star Kari Matchett Kathryn Drummond Guest Star Natalie Dormer Irene Adler Guest Star Ato Essandoh Alfredo Llamosa Guest Star Josh Hamilton Drew Gardner Guest Star Jennifer Ferrin Rebecca Ellison Guest Star J.C. MacKenzie Daren Sutter Guest Star Linda Emond Dr. Candace Reed Guest Star Stephen Kunken Dr. Carrow Guest Star Sean Dougherty Detective Guest Star Justine Cotsonas Jovana Bacera Guest Star Susan Pourfar Emily Hankins Guest Star Chris Bresky Recovering Addict Guest Star Stivi Paskoski Victor Nardin Guest Star Vedant Gokhale Pradeep Singh Guest Star Kristine Johnson TV Reporter Guest Star Robert Doherty Executive Producer, Writer Sarah Timberman Executive Producer Carl Beverly Executive Producer Michael Cuesta Executive Producer, Director Craig Sweeny Writer Liz Friedman Writer Christopher Silber Writer Corinne Brinkerhoff Writer Jeffrey Paul King Writer Peter Blake Writer Brian Rodenbeck Writer John Polson Director John David Coles Director Seith Mann Director Andrew Bernstein Director Peter Werner Director Jason Tracey Writer Christine Moore Director