Jonny Lee Miller Sherlock Holmes Actor Lucy Liu Joan Watson Actor Aidan Quinn Captain Thomas Gregson Actor Jon Michael Hill Detective Marcus Bell Actor Rhys Ifans Mycroft Holmes Guest Star Jordan Gelber M.E. Reginald 'Rex' Hawes Guest Star Sean Pertwee Gareth Lestrade Guest Star Henri Lubatti Marchef Guest Star Ralph Brown Tim Sherrington Guest Star Jonno Roberts Jerome Thomas Guest Star Ronald Guttman Elliot Honeycutt Guest Star Danielle Nicolet Jennifer Sayles Guest Star Jim Norton Sir James Walter Guest Star Stephen Tyrone Williams Randy Guest Star Vincenzo Amato Guillaume de Soto Guest Star Tim Guinee Dean McNally Actor Peter Gerety Frank Da Silva Guest Star Angel Desai Dr. Gretchen Primler Guest Star Mike Starr Russell Gertz Guest Star Ken Marks Chairman Guest Star Robert Doherty Executive Producer, Writer Carl Beverly Executive Producer Sarah Timberman Executive Producer Craig Sweeny Executive Producer, Writer Bob Goodman Writer Jason Tracey Writer Liz Friedman Writer Jeffrey Paul King Writer Cathryn Humphris Writer Guy Ferland Director Sanaa Hamri Director Jerry Levine Director Andrew Bernstein Director Michael Slovis Director Christine Moore Director John Polson Director Larry Teng Director Seith Mann Director